NCIt definition : A benzyl styryl sulfone analog, and a phosphate ester prodrug of ON 013100, with potential
antineoplastic activity. Upon hydrolysis, briciclib is converted to ON 013100, which
blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This
may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D
and eventually decrease tumor cell proliferation. Cyclin D, a member of the cyclin
family of cell cycle regulators, plays a key role in cell cycle division and is often
overexpressed in a variety of hematologic and solid tumors and is correlated with
poor prognosis. suppresses cyclin D1 accumulation in cancer cells.;
Semantic type(s)