Elliptinium - CISMeF

Preferred Label : Elliptinium;

NCIt synonyms : 9-Hydroxy-2-methylellipticinium; 9-Hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium; N-2-Methyl-9-hydroxyellipticinium; NMHE;

NCIt definition : A derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis.;

UNII : 1F1959S062;

InChIKey : YZQRAQOSAPWELU-UHFFFAOYSA-O;

CAS number : 58337-34-1;

Chemical formula : C18H17N2O;

Details

Origin ID

C90495;

UMLS CUI

C0115685;

Currated CISMeF NLP mapping
- elliptinium [MeSH concept]
- elliptinium [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- elliptinium [MeSH concept]
- elliptinium [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Elliptinium Acetate [NCIt concept]
is_free_acid_or_base_form_of
- Elliptinium Acetate [NCIt concept]

Keyword's position in hierarchy(ies) :

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