NCIt definition : A broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal activity.
Similar to carbenicillin in action, ticarcillin inactivates the penicillin-sensitive
transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents
the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last
stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall
synthesis and eventually causes cell lysis.;