NCIt definition : The disodium salt form of ticarcillin, a broad-spectrum, semi-synthetic penicillin
antibiotic with bactericidal and beta-lactamase resistant activity. Similar to carbenicillin
in action, ticarcillin inactivates the penicillin-sensitive transpeptidase C-terminal
domain by opening the lactam ring. This inactivation prevents the cross-linkage of
peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell
wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually
causes cell lysis.;