Benralizumab - CISMeF

Preferred Label : Benralizumab;

NCIt synonyms : Anti-CD125 Humanized Monoclonal Antibody, IgG1-kappa;

NCIt definition : An afucosylated, humanized monoclonal antibody against the alpha chain of the interleukin-5 receptor (IL-5Ra), with potential anti-asthmatic activity. Upon administration, benralizumab binds to IL-5Ra and elicits an antibody-directed cell cytotoxicity (ADCC) against IL-5Ra-expressing cells. This induces apoptosis in IL-5Ra-expressing cells and may reduce asthmatic episodes. IL-5Ra, expressed on both eosinophils and basophils, plays a key role in asthma.;

UNII : 71492GE1FX;

CAS number : 1044511-01-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1044511-01-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Fasenra;

Molecule name : MEDI-563; KHK-4563; BIW-8405;

Codes from synonyms : 34282;

Details

Origin ID

C88594;

UMLS CUI

C2982078;

Automatic exact mappings (from CISMeF team)
- Benralizumab [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Benralizumab (substance) [SNOMED CT concept]
- benralizumab [MeSH concept]
- benralizumab [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing benralizumab (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Benralizumab (substance) [SNOMED CT concept]
- Product containing benralizumab (medicinal product) [SNOMED CT concept]
- benralizumab [MeSH concept]
- benralizumab [MeSH Supplementary Concept]
- benralizumab [ATC Code]
Validated automatic mappings to BTNT
- benralizumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Interleukin-5 Receptor Subunit Alpha [NCIt concept]

Keyword's position in hierarchy(ies) :

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