Preferred Label : Litronesib;
NCIt synonyms : Propanamide, N-[4-(2,2-dimethyl-1-oxopropyl)-5-[[[[2-(ethylamino)ethyl]sulfonyl] amino]methyl]-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-,
(-)-;
NCIt definition : An inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic
activity. Litronesib selectively inhibits the activity of Eg5, which may result in
mitotic disruption, apoptosis and consequently cell death in tumor cells that are
actively dividing. The ATP-dependent Eg5 kinesin-related motor protein (also known
as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein
that plays an essential role during mitosis, particularly in the regulation of spindle
dynamics, including assembly and maintenance.;
UNII : 6611F8KYCV;
InChIKey : YVAFBXLHPINSIK-QHCPKHFHSA-N;
CAS number : 910634-41-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 910634-41-2
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : KF89617; LY2523355;
Chemical formula : C23H37N5O4S2;
Origin ID : C88328;
UMLS CUI : C2981845;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
