Preferred Label : Iodine I-123 ADAM;
NCIt synonyms : Iodine-123-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine; ADAM I-123;
NCIt definition : A radiopharmaceutical containing the serotonin transporter (SERT) ligand ADAM [2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine]
labeled with the radioisotope iodine I 123, with SERT-binding and radioisotope activities.
Upon administration, iodine I 123 ADAM selectively binds to SERT-expressing cells;
subsequently, SERT-expressing tissues may be visualized using single photon emission
computed tomography (SPECT). SERT is a monamine transporter protein found in the membranes
of neurons and platelets; in neurons it transports the neurotransmitter serotonin
from synaptic spaces into presynaptic neurons, terminating serotonin's function.;
UNII : 20LJC2LC2J;
InChIKey : KPKLDBBNSFWOFA-KIWWSDKQSA-N;
CAS number : 305352-16-3;
Chemical formula : C15H17IN2S;
NCI Metathesaurus CUI : CL413579;
Origin ID : C88319;
UMLS CUI : C2981834;
Semantic type(s)
- concept_is_in_subset
- has_target
