Preferred Label : Vorsetzumab Mafodotin;
NCIt synonyms : Anti-CD70 MoAb SGN70-MMAF Conjugate;
NCIt related terms : VORSETUZUMAB MAFODOTIN;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a humanized monoclonal antibody, directed
against the extracellular domain of the human CD70 molecule, conjugated to the auristatin
analogue monomethyl auristatin phenylalanine (MMAF), with potential antineoplastic
activity. The anti-CD70 antibody moiety of vorsetuzumab mafodotin selectively binds
to the extracellular domain of CD70 on tumor cell surfaces. Upon internalization,
the MMAF moiety is released, binds to tubulin and inhibits its polymerization, which
may result in G2/M phase arrest, tumor cell apoptosis and inhibition of cellular proliferation
in tumor cells that overexpress CD70. CD70, the ligand for the costimulatory receptor
CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces
of various types of cancer cells.;
UNII : 699619YVTQ;
CAS number : 1165741-01-4;
Molecule name : SGN-75; SGN 75;
NCI Metathesaurus CUI : CL413570;
Origin ID : C88315;
UMLS CUI : C3642446;
Semantic type(s)
- concept_is_in_subset
- has_target
