Preferred Label : Milciclib Maleate;
NCIt synonyms : N,1,4,4-Tetramethyl-8-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide; 1H-Pyrazolo(4,3-H)quinazoline-3-carboxamide, 4,5-dihydro-N,1,4,4-tetramethyl-8-((4-(4-methyl-1-piperazinyl)phenyl)amino)-,
(2Z)-2-Butenedioate (1:1);
NCIt definition : The maleate salt form of milciclib, an orally bioavailable inhibitor of cyclin-dependent
kinases (CDKs) and tropomyosin receptor kinase A (TRKA), with potential antineoplastic
activity. CDK2/TRKA inhibitor PHA-848125 AC potently inhibits cyclin-dependent kinase
2 (CDK2) and exhibits activity against other CDKs including CDK1 and CDK4, in addition
to TRKA. Inhibition of these kinases may result in cell cycle arrest and apoptosis
of tumor cells that express these kinases. CDKs are serine/threonine kinases involved
in regulation of the cell cycle and may be overexpressed in some cancer cell types.
The neurotrophin receptor TRKA is mutated in a variety of cancer cell types.;
UNII : 82W826FL6S;
InChIKey : DGVCEXQFNYYRQI-BTJKTKAUSA-N;
CAS number : 1253645-38-3;
Molecule name : PHA-848125 AC;
Origin ID : C88312;
UMLS CUI : C4724083;
See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
