Preferred Label : Milciclib;
NCIt synonyms : 1H-Pyrazolo(4,3-h)quinazoline-3-carboxamide, 4,5-dihydro-N,1,4,4-tetramethyl-8-((4-(4-methyl-1-piperazinyl)phenyl)amino)-; N,1,4,4-Tetramethyl-8-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo(4,3-h)quinazoline-3-carboxamide;
NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and tropomyosin
receptor kinase A (TRKA), with potential antineoplastic activity. CDK2/TRKA inhibitor
PHA-848125 AC potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits activity
against other CDKs including CDK1 and CDK4, in addition to TRKA. Inhibition of these
kinases may result in cell cycle arrest and apoptosis of tumor cells that express
these kinases. CDKs are serine/threonine kinases involved in regulation of the cell
cycle and may be overexpressed in some cancer cell types. The neurotrophin receptor
TRKA is mutated in a variety of cancer cell types.;
UNII : 688000M8S8;
InChIKey : RXZMYLDMFYNEIM-UHFFFAOYSA-N;
CAS number : 802539-81-7;
Molecule name : PHA-848125; PHA 848125;
NCI Metathesaurus CUI : CL551003;
Origin ID : C148410;
UMLS CUI : C5400087;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
