Preferred Label : Ang2/VEGF-Binding Peptides-Antibody Fusion Protein CVX-241;
NCIt related terms : CVX-241;
NCIt definition : A fusion protein containing angiopoietin-2 (Ang2) and vascular endothelial growth
factor (VEGF) derived peptides covalently attached, via a proprietary diketone linker,
to a proprietary humanized catalytic aldolase monoclonal antibody, with potential
antiangiogenic and antineoplastic activities. The Ang2/VEGF peptide moieties of Ang2/VEGF-binding
peptides-antibody fusion protein CVX-241 bind to Ang2 and VEGF receptors, which may
inhibit tumor angiogenesis and tumor cell proliferation. The proprietary humanized
catalytic IgG1 monoclonal aldolase antibody contains reactive lysine residues in its
binding sites, which react covalently with compounds having a diketone function; the
Ang2 and VEGFR peptide moieties are then covalently attached to the diketone linkers
via a proprietary spacer. Both VEGF and Ang2 are upregulated in a variety of cancer
cell types and play a crucial role in angiogenesis. This agent possesses an enhanced
half-life compared to the naked peptides.;
UNII : 3RM68C5CTG;
CAS number : 1415642-63-5;
Molecule name : CVX-241; PF-05057459;
NCI Metathesaurus CUI : CL413555;
Origin ID : C88301;
UMLS CUI : C2981818;
Semantic type(s)
- concept_is_in_subset
- has_target
