Inebilizumab - CISMeF

Preferred Label : Inebilizumab;

NCIt definition : A humanized immunoglobulin IgG1 kappa monoclonal antibody directed against the B-cell-specific membrane protein CD-19 with potential immunostimulating and antineoplastic activities. Inebilizumab binds to CD19, which may result in a cytotoxic T-lymphocyte (CTL) response and antibody-dependent cellular cytotoxicity (ADCC) to CD19-expressing B-cells. The Fc portion of inebilizumab does not contain a fucose sugar moiety, which may contribute to its enhanced ADCC activity. CD19 is a membrane antigen that is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages.;

UNII : 74T7185BMM;

CAS number : 1299440-37-1;

Molecule name : MEDI-551;

Details

Origin ID

C88283;

UMLS CUI

C4519594;

Currated CISMeF NLP mapping
- Inebilizumab [SMS substance]
- Inebilizumab (substance) [SNOMED CT concept]
- inebilizumab [MeSH Supplementary Concept]
- inebilizumab [MeSH concept]
Manual BTNT mappings - CISMeF
- inebilizumab [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Inebilizumab (substance) [SNOMED CT concept]
- Product containing inebilizumab (medicinal product) [SNOMED CT concept]
- inebilizumab [MeSH Supplementary Concept]
- inebilizumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- B-Lymphocyte Antigen CD19 [NCIt concept]

Keyword's position in hierarchy(ies) :

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