NCIt definition : A radioconjugate consisting of the somatostatin analogue edotreotide labeled with
lutetium Lu 177 with potential antineoplastic activities. Lutetium Lu 177-edotreotide
binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present
on the cell membranes of many types of neuroendocrine tumor cells. Upon binding and
internalization, this radioconjugate specifically delivers a cytotoxic dose of beta
radiation to SSTR-positive cells. Edotreotide is produced by substituting tyrosine
for phenylalanine at the 3 position of the somatostatin analogue octreotide (Tyr3-octreotide
or TOC) and chelated by the bifunctional, macrocyclic chelating agent dodecanetetraacetic
acid (DOTA).;
UNII : RGO812Q0C8;
InChIKey : XOPYQJXRGHFPOH-NZMVMCJSSA-K;
CAS number : 321835-55-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 321835-55-6
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