" /> Lutetium Lu 177-Edotreotide - CISMeF





Preferred Label : Lutetium Lu 177-Edotreotide;

NCIt synonyms : [177LuDOTA]-TOC; Lutetium Lu 177 DOTA-Tyr3-octreotide; 177Lu-Edotreotide; Lutetium 177Lu-Edotreotide; 177Lu-DOTATOC; 177Lu-Edo; Lutetium Lu177 Edotreotide;

NCIt related terms : EDOTREOTIDE LUTETIUM LU-177;

NCIt definition : A radioconjugate consisting of the somatostatin analogue edotreotide labeled with lutetium Lu 177 with potential antineoplastic activities. Lutetium Lu 177-edotreotide binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present on the cell membranes of many types of neuroendocrine tumor cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. Edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide (Tyr3-octreotide or TOC) and chelated by the bifunctional, macrocyclic chelating agent dodecanetetraacetic acid (DOTA).;

UNII : RGO812Q0C8;

InChIKey : XOPYQJXRGHFPOH-NZMVMCJSSA-K;

CAS number : 321835-55-6;

NCI Metathesaurus CUI : CL412466;

PubMed : 18448552;

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31/05/2025


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