Thioinosine - CISMeF

Preferred Label : Thioinosine;

NCIt synonyms : Mercaptopurine Riboside; 6-mercaptopurine ribonucleoside; inosine, 6-thio; ribosyl-6-mercaptopurine;

NCIt related terms : 6-Mercaptopurine riboside;

NCIt definition : A sulfhydryl analog of inosine and an antimetabolite with potential antineoplastic and immunosuppressive properties. Thioinosine interferes with de novo purine synthesis and perturbs the pool of nucleotides necessary for DNA replication. As a result, this agent inhibits DNA synthesis, blocks cellular proliferation and induces apoptosis.;

UNII : 46S541971T;

InChIKey : NKGPJODWTZCHGF-KQYNXXCUSA-N;

CAS number : 574-25-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 574-25-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C10H12N4O4S;

NSC code : 4911;

Codes from synonyms : NSC0004911;

Details

Origin ID

C877;

UMLS CUI

C0039904;

Currated CISMeF NLP mapping
- thioinosine [Substance BNPC]
- thioinosine [MeSH Descriptor]
- thioinosine [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- thioinosine [Substance BNPC]
- thioinosine [MeSH concept]
- thioinosine [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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