thioinosine - CISMeF

Preferred Label : thioinosine;

MeSH definition : Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503);

MeSH synonym : 6-mercaptopurine riboside; 6 mercaptopurine riboside; riboside, 6-mercaptopurine; ribosyl-6-mercaptopurine; ribosyl 6 mercaptopurine;

MeSH hyponym : NSC-4911;

MeSH CAS label : inosine, 6-thio-;

MeSH Related Number : 574-25-4 (Thioinosine);

Registry Number MeSH : 574-25-4;

Codes EINECS : 209-371-5;

Is substance : O;

UNII : 46S541971T;

InChIKey : NKGPJODWTZCHGF-KQYNXXCUSA-N;

Details

Origin ID

D013868;

UMLS CUI

C0039904;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- thioinosine [Substance BNPC]
Currated CISMeF NLP mapping
- Thioinosine [SMS substance]
- Thioinosine [NCIt concept]
Pharmacological action(s)
- antimetabolites, antineoplastic [MeSH Descriptor]
- immunosuppressive agents [MeSH Descriptor]
Record concept(s)
- NSC-4911 [MeSH concept]
- thioinosine [MeSH concept]
Related MeSH Supplementary Concept(s)
- 2'-deoxy-6-thioinosine [MeSH Supplementary Concept]
- 2-fluoro-4-nitrobenzyl mercaptopurine riboside [MeSH Supplementary Concept]
- 3'-deoxy-3'-thioinosine-3'-dimethylphosphorothiolate [MeSH Supplementary Concept]
- 4-nitrobenzylthioinosine [MeSH Supplementary Concept]
- 5'-isobutylthioinosine [MeSH Supplementary Concept]
- 6-((2-hydroxy-3-iodo-5-nitrobenzyl)thio)-9-ribofuranosylpurine [MeSH Supplementary Concept]
- 6-(2,4-dichlorobenzylthio)-9-ribofuranosylpurine [MeSH Supplementary Concept]
- 6-(4-cyanobenzylthio)-9-ribofuranosylpurine [MeSH Supplementary Concept]
- 6-benzylthioinosine [MeSH Supplementary Concept]
- 6-methylthiopurine ribonucleoside-5'-phosphate [MeSH Supplementary Concept]
- cyclic 6-thioinosine 5'-diphosphate ribose [MeSH Supplementary Concept]
- nitrobenzylthioinosine 5'-monophosphate [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Thioinosine [NCIt concept]
- thioinosine [Substance BNPC]

Keyword's position in hierarchy(ies) :

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