Preferred Label : Mivobulin;
NCIt synonyms : Carbamic Acid, (5-Amino-1,2-Dihydro-2-Methyl-3-Phenylpyrido(3,4-B)Pyrazin-7-Yl) Ethyl
Ester, (S)-; Ethyl (S)-5-Amino-1,2-Dihydro-2-Methyl-3-Phenylpyrido(3,4-B)Pyrazine-7-Carbamate;
NCIt definition : A synthetic, colchicine analogue with potential antineoplastic activity. Mivobulin
targets and binds to colchicine-binding site on tubulin, thereby inhibiting microtubule
polymerization, the assembly of the mitotic spindle and mitosis. This eventually results
in cell cycle arrest, apoptosis and a reduction in cellular proliferation.;
UNII : 96U5LG549X;
InChIKey : XXBDOTXPQDVHIP-JTQLQIEISA-N;
CAS number : 122332-18-7;
Chemical formula : C17H19N5O2;
Origin ID : C87698;
UMLS CUI : C2981335;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
