NCIt synonyms : Human Serum Albumin (585 Residues) Fusion Protein with Human Interferon Alpha-2 (165
Residues); 1-585-Serum Albumin (Human) Fusion Protein with Interferon Alpha-2b (Human);
NCIt definition : A long-acting, recombinant fusion polypeptide consisting of interferon alpha-2b (IFNa-2b)
linked to human albumin (alb-IFN), with antiviral and immunomodulatory activity. Albinterferon
alpha-2b binds to specific cell-surface receptors, resulting in the expression of
genes whose protein products mediate antiviral, antiproliferative, and immune-modulating
effects. Conjugation of interferon to human albumin prolongs the half-life of IFNa-2b
and thereby allows for a reduction in the frequency of dosing.;