Preferred Label : Vinzolidine Sulfate;
NCIt synonyms : Methyl (3R,5S,7R,9S)-9-[3'-(2-Chloroethyl)-6,7-Didehydro-4Beta-Hydroxy-16-Methoxy-1-Methyl-2',4'-Dioxo-2Beta,3Beta,5Alpha,12Beta,19Alpha-Spiro(Aspidospermidine-3,5'-Oxazolidin]-15-yl)-5-Ethyl-1,4,5,6,7,8,9,10-Octahydro-5-Hydroxy-2H-3,7-Methano; 2h-3,7-Methanoazacycloundecino(5,4-Beta)Indole-9-Carboxylic Acid, 9-((2Beta,3Beta,4Beta,5Alpha,12Beta,19Alpha)-4-(Acetyloxy)-3'-(2-Chloroethyl)-6,7-Didehydro-16-Methoxy-1-Methyl-2',4'-Dioxospiro(Aspidospermidine-3,5'-Oxazolidin)-15-Yl)-5-Ethy;
NCIt definition : The sulfate salt of vinzolidine, an orally active semisynthetic vinca alkaloid with
potential antineoplastic activity. Like other vinca alkaloid compounds, vinzolidine
binds to and stabilizes tubulin molecules, thereby interfering with microtubule assembly/disassembly
dynamics. As a result, vinzolidine prevents mitotic spindle formation and leads to
cell cycle arrest in metaphase.;
UNII : 78NZ2PMP25;
InChIKey : LPDLEICKXUVJHW-QJILNLRNSA-N;
CAS number : 67699-41-6;
Molecule name : LY104208;
Chemical formula : C48H58ClN5O9.H2O4S;
Origin ID : C87288;
UMLS CUI : C2828244;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
