Vinzolidine - CISMeF

Preferred Label : Vinzolidine;

NCIt synonyms : 2H-3,7-Methanoazacycloundecino(5,4-b)indole-9-carboxylic acid, 9-((2-beta,3-beta,4-beta,5-alpha,12-beta,19-alpha)-4-(acetyloxy)-3'-(2-chloroethyl)-6,7-didehydro-16-methoxy-1-methyl-2',4'-dioxospiro(aspidospermidine-3,5'-oxazolidin)-15-yl)-5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-, methyl ester, (3R-(3R*,5S*,7R*,9S*))-;

NCIt definition : An orally active semisynthetic vinca alkaloid with potential antineoplastic activity. Like other vinca alkaloid compounds, vinzolidine binds to and stabilizes tubulin molecules, thereby interfering with microtubule assembly/disassembly dynamics. As a result, vinzolidine prevents mitotic spindle formation and leads to cell cycle arrest in metaphase.;

UNII : 533U947V6Q;

InChIKey : MMRCWWRFYLZGAE-ZBZRSYSASA-N;

CAS number : 67699-40-5;

Chemical formula : C48H58ClN5O9;

Details

Origin ID

C1276;

UMLS CUI

C0078282;

Currated CISMeF NLP mapping
- vinzolidine [Substance BNPC]
- vinzolidine [MeSH concept]
- vinzolidine [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- vinzolidine [Substance BNPC]
- vinzolidine [MeSH concept]
- vinzolidine [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Vinzolidine Sulfate [NCIt concept]
is_free_acid_or_base_form_of
- Vinzolidine Sulfate [NCIt concept]

Keyword's position in hierarchy(ies) :

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