Preferred Label : Vinzolidine;
NCIt synonyms : 2H-3,7-Methanoazacycloundecino(5,4-b)indole-9-carboxylic acid, 9-((2-beta,3-beta,4-beta,5-alpha,12-beta,19-alpha)-4-(acetyloxy)-3'-(2-chloroethyl)-6,7-didehydro-16-methoxy-1-methyl-2',4'-dioxospiro(aspidospermidine-3,5'-oxazolidin)-15-yl)-5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-,
methyl ester, (3R-(3R*,5S*,7R*,9S*))-;
NCIt definition : An orally active semisynthetic vinca alkaloid with potential antineoplastic activity.
Like other vinca alkaloid compounds, vinzolidine binds to and stabilizes tubulin molecules,
thereby interfering with microtubule assembly/disassembly dynamics. As a result, vinzolidine
prevents mitotic spindle formation and leads to cell cycle arrest in metaphase.;
UNII : 533U947V6Q;
InChIKey : MMRCWWRFYLZGAE-ZBZRSYSASA-N;
CAS number : 67699-40-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 67699-40-5
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G-SRS /a ;
Chemical formula : C48H58ClN5O9;
Origin ID : C1276;
UMLS CUI : C0078282;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
