Deflazacort - CISMeF

Preferred Label : Deflazacort;

NCIt synonyms : 11Beta,21-Dihydroxy-2'-Methyl-5'Beta-H-Pregna-1,4-Dieno(17,16-D)Oxazole-3,20-Dione 21-Acetate; 5'H-Pregna-1,4-Dieno(17,16-d)Oxazole-3,20-Dione, 21-(Acetyloxy)-11-Hydroxy-2'-Methyl-, (11Beta,16Beta)-;

NCIt definition : A synthetic glucocorticoid prodrug, with anti-inflammatory and immunomodulating properties. Upon administration, the active metabolite of deflazacort, 21-desacetyl deflazacort, binds to and activates tissue glucocorticoid receptors. This results in the inhibition of specific leukocyte functions and the inhibition of proinflammatory cytokine production.;

UNII : KR5YZ6AE4B;

InChIKey : FBHSPRKOSMHSIF-GRMWVWQJSA-N;

CAS number : 14484-47-0;

Drug name : Emflaza;

Molecule name : MDL 458;

Chemical formula : C25H31NO6;

Details

Origin ID

C87230;

UMLS CUI

C0057258;

Currated CISMeF NLP mapping
- Deflazacort [ICD-11 Extension code]
- Deflazacort (substance) [SNOMED CT concept]
- Product containing deflazacort (medicinal product) [SNOMED CT concept]
- deflazacort [Substance BNPC]
- deflazacort [MeSH concept]
- deflazacort [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Deflazacort [ICD-11 Extension code]
- Deflazacort (substance) [SNOMED CT concept]
- Product containing deflazacort (medicinal product) [SNOMED CT concept]
- deflazacort [ATC Code]
- deflazacort [Substance BNPC]
- deflazacort [MeSH concept]
- deflazacort [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- deflazacort [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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