Aggressive NK-Cell Leukemia

Preferred Label : Aggressive NK-Cell Leukemia;

NCIt synonyms : Aggressive NK-Cell Leukemia/Lymphoma; NK-Cell Leukemia; Natural Killer Cell Leukemia; NK Cell Leukemia;

NCIt related terms : Aggressive NK-cell leukaemia;

NCIt definition : A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers and young adults. It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen.;

Neoplastic status : Malignant;

ICD-O code : 9948/3;

Details

Origin ID

C8647;

UMLS CUI

C1292777;

Automatic exact mappings (from CISMeF team)
- leukemia, large granular lymphocytic [MeSH Descriptor]
Currated CISMeF NLP mapping
- Aggressive NK cell leukaemia [ICD-11 Subcategory]
- Aggressive NK-cell leukaemia [ICD-11 Extension code]
- Aggressive NK-cell leukemia [ICD-O code]
- Aggressive NK-cell leukemia [ORDO Disease]
- Aggressive natural killer-cell leukemia (disorder) [SNOMED CT concept]
- Aggressive natural killer-cell leukemia (morphologic abnormality) [SNOMED CT concept]
- Leukemia, aggressive NK-cell [SNOMED Notion]
- NK-cell leukaemia [MedDRA LLT]
- NK-cell leukemia [MedDRA LLT]
- Natural killer-cell leukaemia [MedDRA Preferred Term]
- Natural killer-cell leukemia [MedDRA LLT]
- aggressive NK cell leukemia [Disease (Nov.)]
- aggressive NK-cell leukemia [DO Concept]
DO Cross reference
- aggressive NK-cell leukemia [DO Concept]
Disease excludes abnormal cell
- Leukemic Plasma Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor Natural Killer Cell [NCIt concept]
- Precursor T-Lymphoblast [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Angioinvasion [NCIt concept]
- Fever [NCIt concept]
- Granulocytopenia [NCIt concept]
- Hemophagocytosis [NCIt concept]
- Hepatomegaly [NCIt concept]
- Lymphadenopathy [NCIt concept]
- Necrotic Change [NCIt concept]
- Serum Soluble Fas Ligand Level Increased [NCIt concept]
- Splenomegaly [NCIt concept]
- Thrombocytopenia [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Aggressive NK-cell leukemia [ORDO Disease]
- Aggressive NK-cell leukemia [ICD-O code]
- Aggressive natural killer-cell leukemia (disorder) [SNOMED CT concept]
- Aggressive natural killer-cell leukemia (morphologic abnormality) [SNOMED CT concept]
- Leukemia, aggressive NK-cell [SNOMED Notion]
- NK-cell leukaemia [MedDRA LLT]
- NK-cell leukemia [MedDRA LLT]
- Natural killer-cell leukaemia [MedDRA Preferred Term]
- Natural killer-cell leukemia [MedDRA LLT]
- aggressive NK cell leukemia [Disease (Nov.)]
- aggressive NK-cell leukemia [DO Concept]
Validated automatic mappings to BTNT
- Aggressive natural killer-cell leukemia involving skin (disorder) [SNOMED CT concept]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Acute Clinical Course [NCIt concept]
- Benign Cellular Infiltrate [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Leukemic Cell [NCIt concept]
- Leukemic Lymphocyte [NCIt concept]
- Leukemic Natural Killer Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
disease_has_finding
- CD56-Positive Neoplastic Cells Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Natural Killer Cell [NCIt concept]
- Peripheral (Post-Thymic) T-Lymphocyte and Natural Killer Cell [NCIt concept]
- T-Lymphocyte and Natural Killer Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
- Coagulation Disorder [NCIt concept]
- EBV Infection [NCIt concept]
- Nasal Type Extranodal NK/T-Cell Lymphoma [NCIt concept]
disease_may_have_cytogenetic_abnormality
- del(6q21q25) [NCIt concept]

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