Preferred Label : Recombinant Adenovirus Encoding p53;
NCIt synonyms : rAd-p53;
NCIt definition : A replication-defective, recombinant adenoviral vector encoding the wild-type human
tumor-suppressor protein p53 gene with potential antineoplastic activity. Upon intratumoral
administration, rAD-p53 binds to the coxsackie-and-adenovirus receptor (CAR) on tumor
cells and enters cells selectively via receptor-mediated endocytosis, which may result
in the overexpression of wild-type p53 intracellularly and p53-mediated tumor regression.
In addition, this agent may stimulate the immune system to mount a cytotoxic T-lymphocyte
(CTL) immune response against tumor cells, may activate natural killer (NK) cells
to exert antitumor 'bystander effects' and may downregulate the expression of various
oncogenes. The p53 protein blocks tumor cell cycle progression and directly initiates
apoptosis; the p53 gene, a tumor suppressor gene, is deleted or mutated in a significant
number of cancers.;
Drug name : Gendicine; Genkaxin;
NCI Metathesaurus CUI : CL412342;
Origin ID : C85485;
UMLS CUI : C1514767;
Semantic type(s)
- concept_is_in_subset
