Anti-A5B1 Integrin Monoclonal Antibody PF-04605412

Preferred Label : Anti-A5B1 Integrin Monoclonal Antibody PF-04605412;

NCIt synonyms : Anti-alpha5beta1 Integrin Monoclonal Antibody PF-04605412;

NCIt related terms : PF-04605412;

NCIt definition : A monoclonal antibody directed against the human alpha5beta1 integrin with potential antiangiogenic and antineoplastic activities. Anti-alpha5beta1 integrin monoclonal antibody PF-04605412 selectively binds to alpha5beta1 integrin, preventing the binding of integrin ligands. This may result in the inhibition of endothelial cell-cell interactions, endothelial cell-matrix interactions, and integrin-mediated tumor angiogenesis and metastasis in alpha5beta1-expressing tumor cells. Alpha5beta1 integrin, a cell adhesion and signaling receptor, is often overexpressed on the surface of tumor vessel endothelial cells and plays a crucial role in endothelial cell adhesion and migration.;

UNII : CFN88ESH2J;

Molecule name : PF-04605412;

Details

Origin ID

C85478;

UMLS CUI

C2827700;

Currated CISMeF NLP mapping
- PF-04605412 [MeSH Supplementary Concept]
Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Integrin Alpha5/Beta1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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