NCIt definition : An orally bioavailable tartrate salt of vinorelbine, a semisynthetic vinca alkaloid
with potential antineoplastic activity. Vinorelbine binds to tubulin, thereby inhibiting
tubulin polymerization into microtubules and spindle formation and resulting in apoptosis
of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor
activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's
neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective
against mitotic than axonal microtubules in vitro, which may account for its decreased
neurotoxicity. This agent is also a radiation-sensitizing agent.;
Manual NTBT mappings (CISMeF)