IDH2 wt Allele

Preferred Label : IDH2 wt Allele;

NCIt synonyms : ICD-M; IDHM; mNADP-IDH; IDP; Isocitrate Dehydrogenase 2 (NADP ), Mitochondrial wt Allele; IDH; IDPM; D2HGA2;

NCIt definition : Human IDH2 wt allele is located in the vicinity of 15q26.1 and is approximately 18 kb in length. This allele, which encodes isocitrate dehydrogenase 2 (NADP ) mitochondrial protein, plays a role in intermediary metabolism. Mutations in this gene are associated with astrocytoma, oligodendroglioma and secondary glioblastoma.;

GenBank Accession Number : NM_002168;

Details

Origin ID

C84949;

UMLS CUI

C2827560;

False automatic mappings
- D-2-hydroxyglutaric aciduria 2 [OMIM Phenotype]
OMIM relation
- Isocitrate dehydrogenase 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Astrocytoma [NCIt concept]
- Oligodendroglioma [NCIt concept]
- Secondary Glioblastoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 15q26.1 [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Anaplastic Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted [NCIt concept]
- Astrocytoma, IDH-Mutant [NCIt concept]
- Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted [NCIt concept]
gene_plays_role_in_process
- Intermediary Metabolic Process [NCIt concept]
- Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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