Preferred Label : Combretastatin A1 Diphosphate;
NCIt synonyms : Combretastatin A-1 bis(phosphate); CA1P; 1,2-Benzenediol, 3-methoxy-6-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, 1,2-bis(dihydrogen
Phosphate);
NCIt related terms : OXI-4503;
NCIt definition : The diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from
the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities.
Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the
active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization;
endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature,
disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone
intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be
elevated in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins
and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide
production. CA1 binds to tubulin at the same site as colchicine but with higher affinity.;
UNII : JH6Z94GLUD;
InChIKey : GSOXMQLWUDQTNT-WAYWQWQTSA-N;
CAS number : 288847-35-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 288847-35-8
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : OXi4503; OXI 4503;
Chemical formula : C18H22O12P2;
Origin ID : C84867;
UMLS CUI : C2827544;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
