Preferred Label : Combretastatin A-1;
NCIt synonyms : CA1; Combretastatin A1; 1,2-Benzenediol, 3-Methoxy-6-(2-(3,4,5-trimethoxyphenyl)ethenyl)-, (Z)-;
NCIt definition : A stilbenoid originally isolated from the plant Combretum caffrum, with vascular-disrupting
and antineoplastic activities. Upon administration, combretastatin A1 (CA1) promotes
rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis;
destruction of the tumor vasculature; disruption of tumor blood flow; and tumor cell
necrosis. In addition, orthoquinone intermediates, metabolized from combretastatin
A1 by oxidative enzymes found to be elevated in some tumor types, may bind to tumor
cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by
enhancing superoxide/hydrogen peroxide production.;
UNII : 2222ATS339;
InChIKey : YUSYSJSHVJULID-WAYWQWQTSA-N;
CAS number : 109971-63-3;
NCI Metathesaurus CUI : CL970855;
NSC code : 600032;
Origin ID : C162344;
UMLS CUI : C0640658;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
