Preferred Label : Anti-CD70 Antibody-Drug Conjugate MDX-1203;
NCIt synonyms : Anti-CD70 ADC MDX-1203;
NCIt definition : An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody, directed
against the extracellular domain of the human CD70 molecule, conjugated to a prodrug
of a CC-1065 (rachelmycin) analogue via a stable peptide-based linker, with potential
antineoplastic activity. The anti-CD70 antibody moiety of the anti-CD70 antibody-drug
conjugate MDX-1203 selectively binds to the extracellular domain of CD70 on tumor
cell surfaces. Upon internalization, the prodrug moiety is released and activated
and binds to double-stranded B-DNA within the minor groove, thereby alkylating the
-3 position of adenine, which may result in the inhibition of cellular proliferation
of tumor cells that overexpress CD70. CD70, the ligand for the costimulatory receptor
CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces
of various types of cancer cells. The antitumor antibiotic CC-1065, a DNA minor-groove-binding
alkylating agent, was originally isolated from the bacterium Streptomyces zelensis.;
Molecule name : MDX-1203;
Origin ID : C84855;
UMLS CUI : C2827532;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
