PI3K/mTOR Kinase Inhibitor PF-04691502

Preferred Label : PI3K/mTOR Kinase Inhibitor PF-04691502;

NCIt related terms : PF-04691502;

NCIt definition : An agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor PF-04691502 inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.;

UNII : 4W39NS61KI;

CAS number : 1013101-36-4;

Molecule name : PF-04691502;

Details

Origin ID

C84837;

UMLS CUI

C2827515;

Currated CISMeF NLP mapping
- PF-04691502 [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PF-04691502 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase [NCIt concept]

Keyword's position in hierarchy(ies) :

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