Streptonigrin - CISMeF

Preferred Label : Streptonigrin;

NCIt synonyms : STN; Rufocromomycin; 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid; 5-Amino-6-(70-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid;

NCIt related terms : Bruneomycin;

NCIt definition : An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. (NCI04);

UNII : 261Q3JB310;

InChIKey : PVYJZLYGTZKPJE-UHFFFAOYSA-N;

CAS number : 3930-19-6;

Molecule name : PC-501; BA-163;

Chemical formula : C25H22N4O8;

NSC code : 83950; 45383;

ChEBI ID : CHEBI:9287;

Codes from synonyms : NSC0045383; 31698; NSC0083950;

Details

Origin ID

C844;

UMLS CUI

C0038427;

Currated CISMeF NLP mapping
- Rufocromomycin [ICD-11 Extension code]
- rufocromomycin [Substance BNPC]
- streptonigrin [MeSH Descriptor]
- streptonigrin [MeSH concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Rufocromomycin [ICD-11 Extension code]
- rufocromomycin [Substance BNPC]
- streptonigrin [MeSH concept]
- streptonigrin [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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