Preferred Label : Nemorubicin Hydrochloride;
NCIt synonyms : 5,12-Naphthacenedione, 7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxy-10-((2,3,6-Trideoxy-3-((2S)-2-Methoxy-4-Morpholinyl)-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-,
Hydrochloride, (8S,10S)-;
NCIt definition : The hydrochloride salt form of nemorubicin, a morpholinyl analogue of the anthracycline
doxorubicin with antineoplastic activity. Nemorubicin is metabolized via the P450
CYP3A enzyme to a highly cytotoxic derivative. Unlike most anthracyclines, nemorubicin
is a topoisomerase I inhibitor and appears to exert its effect through the nucleotide
excision repair (NER) system. In addition, this agent does not show cross-resistance
with other anthracyclines.;
UNII : 2Q6F8JYX76;
InChIKey : DSXDXWLGVADASF-QQFKZXDBSA-N;
CAS number : 108943-08-4;
Chemical formula : C32H37NO13.HCl;
Origin ID : C84000;
UMLS CUI : C2827284;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
