Nemorubicin - CISMeF

Preferred Label : Nemorubicin;

NCIt definition : A morpholinyl analogue of the anthracycline doxorubicin with antineoplastic activity. Nemorubicin is metabolized via the P450 CYP3A enzyme to a highly cytotoxic derivative. Unlike most anthracyclines, nemorubicin is a topoisomerase I inhibitor and appears to exert its effect through the nucleotide excision repair (NER) system. In addition, this agent does not show cross-resistance with other anthracyclines.;

UNII : 7618O47BQM;

InChIKey : CTMCWCONSULRHO-UHQPFXKFSA-N;

CAS number : 108852-90-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 108852-90-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C32H37NO13;

ChEBI ID : CHEBI:42053;

Details

Origin ID

C83999;

UMLS CUI

C2827283;

Automatic exact mappings (from CISMeF team)
- methoxy-morpholinyl-doxorubicin [MeSH concept]
Currated CISMeF NLP mapping
- nemorubicin [MeSH concept]
- nemorubicin [MeSH Supplementary Concept]
See also inter- (CISMeF)
- methoxy-morpholinyl-doxorubicin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- nemorubicin [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Nemorubicin Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Nemorubicin Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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