Ifenprodil - CISMeF

Preferred Label : Ifenprodil;

NCIt synonyms : 1-Piperidineethanol, 4-Benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-; 2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propanol;

NCIt definition : An orally bioavailable, N-methyl-D-aspartate (NMDA) receptor antagonist, with potential central nervous system (CNS) stimulating, neuroprotective, anti-inflammatory and anti-fibrotic activities. Upon administration, ifenprodil targets, binds to and inhibits glutamanergic NMDA receptors (NMDARs), specifically the glycine-binding NMDA receptor subunit 1 (GluN1) and 2 (glutamate-binding NMDA receptor subunit 2; NMDA-type subunit 2B; GluN2B), thereby preventing NMDAR signaling. This inhibits neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Additionally, ifenprodil inhibits G protein-coupled inwardly-rectifying potassium (GIRK) channels, and interacts with alpha1 adrenergic, serotonin, and activates sigma receptors. Ifenprodil exerts its anti-inflammatory effect through its effect on NMDA and possibly sigma-1 receptors. Although the exact mechanism has not fully been elucidated, this agent reduces the infiltration of neutrophils and T-cells into the lungs and prevents the release of pro-inflammatory cytokines. This may result in the reduction of the lung inflammatory response, inhibit fibrosis in the lungs and may reduce the severity of cough. NMDA receptors are multimeric ionotropic glutamate receptors composed of four subunits and are expressed on various cells and organs, such as in the brain, lungs, and on T-cells and neutrophils.;

UNII : R8OE3P6O5S;

InChIKey : UYNVMODNBIQBMV-UHFFFAOYSA-N;

CAS number : 23210-56-2;

Drug name : Cerocral;

Molecule name : NP-120;

Chemical formula : C21H27NO2;

Origin ID

C83782;

UMLS CUI

C0063340;

CISMeF manual mappings
- Ifenprodil (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ifenprodil [ICD-11 Extension code]
- Ifenprodil (substance) [SNOMED CT concept]
- ifenprodil [ATC Code]
- ifenprodil [Substance BNPC]
- ifenprodil [MeSH concept]
- ifenprodil [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- ifenprodil [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Details

Main resources

You can consult :