Betahistine - CISMeF

Preferred Label : Betahistine;

NCIt definition : A histamine analog with weak histamine H1 agonistic and more potent histamine H3 antagonistic properties. Upon intranasal administration, betahistine binds to histamine H1 and H3 receptors and exerts its agonistic and antagonistic actions locally and centrally. This promotes cochlear, vestibular and cerebral blood flow, decreases neuronal firing in the vestibular nuclei and increases histamine synthesis and release in the brain which facilitates vestibular compensation. Increased blood flow around the inner ear reduces the amount of fluid in the inner ear and may alleviate vertigo, tinnitus, and hearing loss.;

UNII : X32KK4201D;

InChIKey : UUQMNUMQCIQDMZ-UHFFFAOYSA-N;

CAS number : 5638-76-6;

Chemical formula : C8H12N2;

ChEBI ID : CHEBI:35677;

Details

Origin ID

C83554;

UMLS CUI

C0005301;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Betahistine [Substance BNPC]
- Betahistine [ICD-11 Extension code]
- Betahistine (substance) [SNOMED CT concept]
- Product containing betahistine (medicinal product) [SNOMED CT concept]
- betahistine [ATC Code]
- betahistine [MeSH concept]
- betahistine [MeSH Descriptor]
Validated automatic mappings to BTNT
- betahistine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Betahistine Hydrochloride [NCIt concept]
- Betahistine Hydrochloride Nasal Spray [NCIt concept]
is_free_acid_or_base_form_of
- Betahistine Hydrochloride [NCIt concept]
- Betahistine Hydrochloride Nasal Spray [NCIt concept]

Keyword's position in hierarchy(ies) :

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