NCIt definition : A nasal spray containing the hydrochloride salt form of betahistine, a histamine analog
with weak histamine H1 agonistic and more potent histamine H3 antagonistic properties.
Upon intranasal administration, betahistine binds to histamine H1 and H3 receptors
and exerts its agonistic and antagonistic actions locally and centrally. This promotes
cochlear, vestibular and cerebral blood flow, decreases neuronal firing in the vestibular
nuclei and increases histamine synthesis and release in the brain which facilitates
vestibular compensation.;
Semantic type(s)