Radgocitabine - CISMeF

Preferred Label : Radgocitabine;

NCIt synonyms : 4-Amino-L-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)- 2(1H)-pyrimidinone; CNDAC; Deoxycytidine Analogue TAS-109;

NCIt definition : An analogue of the nucleoside deoxycytidine with potential antineoplastic activity. Upon administration, radgocitabine is incorporated into DNA and directly inhibits the activity of DNA polymerase, which may result in inhibition of DNA replication and cell cycle arrest in the S and G2/M phases, DNA fragmentation, and tumor cell apoptosis.;

UNII : 00M634HD2V;

InChIKey : DCYBPMFXJCWXNB-JWIUVKOKSA-N;

CAS number : 135598-68-4;

Molecule name : TAS-109;

NCI Metathesaurus CUI : CL388479;

Details

Origin ID

C82697;

UMLS CUI

C0091023;

Automatic exact mappings (from CISMeF team)
- 2'-cyano-2'-deoxyarabinofuranosylcytosine [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 2'-cyano-2'-deoxyarabinofuranosylcytosine [MeSH Supplementary Concept]
- 2'-cyano-2'-deoxyarabinofuranosylcytosine [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA Polymerase [NCIt concept]

Keyword's position in hierarchy(ies) :

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