Radgocitabine Hydrochloride

Preferred Label : Radgocitabine Hydrochloride;

NCIt synonyms : CNDAC Hydrochloride; 2'-Cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine Monohydrochloride; Deoxycytidine Analogue TAS-109 Hydrochloride;

NCIt definition : The hydrochloride salt form of radgocitabine, an analogue of the nucleoside deoxycytidine with potential antineoplastic activity. Upon administration, radgocitabine is incorporated into DNA and directly inhibits the activity of DNA polymerase, which may result in inhibition of DNA replication and cell cycle arrest in the S and G2/M phases, DNA fragmentation, and tumor cell apoptosis.;

UNII : VSS4ZDZ2IE;

InChIKey : PKGUOXDXRLGZBN-KUAPJGQRSA-N;

CAS number : 134665-72-8;

NCI Metathesaurus CUI : CL552242;

Details

Origin ID

C150430;

UMLS CUI

C5446324;

Automatic exact mappings (from CISMeF team)
- Emitefur [MeSH concept]
- Emitefur [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Emitefur [MeSH Supplementary Concept]
- Emitefur [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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