Preferred Label : MEK Inhibitor RO4987655;
NCIt synonyms : MEK Serine Threonine Kinase Inhibitor RO4987655;
NCIt related terms : RO-4987655;
NCIt definition : An orally active small molecule, targeting mitogen-activated protein kinase kinase
1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor RO4987655
binds to and inhibits MEK, which may result in the inhibition of MEK-dependent cell
signaling and the inhibition of tumor cell proliferation. MEK, a dual specificity
threonine/tyrosine kinase, is a key component of the RAS/RAF/MEK/ERK signaling pathway
that regulates cell growth; constitutive activation of this pathway has been implicated
in many cancers.;
UNII : I3733P75ML;
CAS number : 874101-00-5;
Molecule name : RO4987655;
Origin ID : C82696;
UMLS CUI : C2830219;
Semantic type(s)
- concept_is_in_subset
- has_target
