NCIt synonyms : Heat Shock Protein 90 Inhibitor AB-010;
NCIt definition : An orally bioavailable nanoparticle albumin-bound inhibitor of heat shock protein
90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor AB-010 selectively
binds to Hsp90, inhibiting its chaperone function and promoting the degradation of
oncogenic signaling proteins involved in tumor cell proliferation and survival. This
agent may inhibit the growth of a wide variety of cancer cell types; the incorporation
of albumin into its formulation may facilitate its endothelial transcytosis through
the gp60-regulated albumin transport pathway. Hsp90, a chaperone protein upregulated
in a variety of tumor cells, regulates the folding and degradation of many oncogenic
signaling proteins.;
Semantic type(s)