Preferred Label : Irinotecan-Eluting Beads;
NCIt synonyms : Irinotecan Hydrochloride Drug-eluting Beads;
NCIt definition : Microporous hydrospheres of polyvinylalcohol (PVA) impregnated with irinotecan with
potential antineoplastic activity. In transarterial chemoembolization (TACE), irinotecan-eluting
beads are administered into blood vessels that feed the tumor, occluding tumor blood
vessels and inducing ischemic tumor necrosis while simultaneously delivering high-dose
chemotherapy locally. Irinotecan, a semisynthetic derivative of camptothecin, inhibits
topoisomerase I activity by stabilizing the cleavable complex between topoisomerase
I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic
cell death.;
Molecule name : CM-BC2;
NCI Metathesaurus CUI : CL388467;
Origin ID : C82682;
UMLS CUI : C2826380;
Semantic type(s)
- concept_is_in_subset
- has_target
