Preferred Label : Irinotecan Sucrosofate;
NCIt synonyms : Nanoliposomal Irinotecan; nal-IRI; Nanoparticle Liposome Formulation of Irinotecan; Liposome-Encapsulated Irinotecan Hydrochloride PEP02; inotecan Hydrochloride as Sucrosulfate Salt Form Liposomal Formulation; Nanoliposomal Irinotecan as Sucrosofate; Irinotecan Sucrosofate Liposome; Irinotecan Sucrosofate-containing Pegylated Liposomal Formulation;
NCIt related terms : Irinotecan liposome;
NCIt definition : A liposomal dispersion formulated with the semisynthetic camptothecin analogue irinotecan,
provided as the hydrochloride trihydrate form, which is encapsulated and entrapped
within liposomes in a gelated or precipitated state as the irinotecan sucrose octasulfate
(sucrosulfate) salt form, with potential antineoplastic activity. Upon administration
of the liposomes containing irinotecan sucrosulfate, irinotecan, a prodrug, is converted
to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting
enzyme. During the S-phase, SN-38 inhibits topoisomerase I activity by stabilizing
the cleavable complex between topoisomerase I and DNA, inhibiting religation of topoisomerase
I-mediated single-strand DNA breaks and producing lethal double-strand DNA breaks
when complexes are encountered by the DNA replication machinery. Liposome encapsulation
of this agent promotes efficient drug delivery into the cytosol from the endosome
compartment of the cell, extends the circulation of irinotecan, and prolongs the duration
of active therapy at the site of tumor to inhibit tumor growth.;
UNII : OL741S3N8B;
CAS number : 1361317-83-0;
Drug name : Onivyde;
Molecule name : PEP-02; MM-398; MM 398; PEP 02;
Codes from synonyms : 281;
Origin ID : C82676;
UMLS CUI : C3712210;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
