" /> Irinotecan Sucrosofate - CISMeF





Preferred Label : Irinotecan Sucrosofate;

NCIt synonyms : Nanoliposomal Irinotecan; nal-IRI; Nanoparticle Liposome Formulation of Irinotecan; Liposome-Encapsulated Irinotecan Hydrochloride PEP02;

NCIt related terms : Irinotecan liposome;

NCIt definition : A liposomal formulation of the semisynthetic camptothecin analogue irinotecan with potential antineoplastic activity. During the S phase of the cell cycle, irinotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Liposome encapsulation of this agent promotes efficient drug delivery into the cytosol from the endosome compartment of the cell.;

UNII : OL741S3N8B;

CAS number : 1361317-83-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1361317-83-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Onivyde;

Molecule name : PEP-02; MM-398; MM 398;

Codes from synonyms : 281;

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16/05/2024


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