Preferred Label : Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981;
NCIt synonyms : Oral Pan-VEGFR TIE2 Tyrosine Kinase Inhibitor CEP-11981; ESK-981; 4H-Indazolo(5,4-a)pyrrolo(3,4-C)carbazol-4-one, 2,5,6,11,12,13-Hexahydro-2-methyl-11-(2-methylpropyl)-8-(2-pyrimidinylamino)-;
NCIt related terms : CEP-11981;
NCIt definition : An orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR)
and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic
activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to
VEGFR and Tie2 receptor tyrosine kinases, which may result in the inhibition of endothelial
cell migration, proliferation and survival and the inhibition of tumor cell proliferation
and tumor cell death. VEGFR and Tie2 are frequently overexpressed by a variety of
tumor cell types and play crucial roles in the regulation of angiogenesis and the
maintenance of tumor blood vessels. Tie2 (tyrosine kinase with immunoglobulin-like
and EGF-like domains) is activated by angiopoietin-1 (Ang-1).;
UNII : J8AY0Z4CBP;
InChIKey : AEULIVPVIDOLIN-UHFFFAOYSA-N;
CAS number : 856691-93-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 856691-93-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : CEP-11981; CEP 11981; ESK 981; BOL-303213X; ESK981;
Origin ID : C82379;
UMLS CUI : C2830064;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
