Preferred Label : Anti-CD19/Anti-CD22 Bispecific Immunotoxin DT2219ARL;
NCIt synonyms : Anti-CD19/CD22 BLT DT2219ARL; Anti-CD19 Anti-CD22 Bispecific Immunotoxin DT2219ARL;
NCIt related terms : DT2219ARL immunotoxin;
NCIt definition : An immunotoxin consisting of two scFv ligands recognizing human CD19 and CD22 linked
to the first 389 amino acids of diphtheria toxin (DT), DT 390, with potential antineoplastic
activity. The VH and VL regions of anti-CD22 (sFv) and anti-CD19 are reversed and
linked by an aggregration stabilizing linker (ARL) consisting of a 20 amino acid segment
of human muscle aldolase (hma) and an Xho1-compatible restriction site; the CDR3 region
of the VH of anti-CD22 sFv is mutated to enhance its affinity. The anti-CD19 and anti
CD-22 portions of the immunotoxin specifically bind to CD19 and CD22 receptors on
tumor B cells. Upon internalization, DT catalyzes ADP ribosylation of elongation factor
2 (EF-2) which may result in the irreversible inhibition of protein synthesis and
cell death in CD19- and CD22-expressing tumor cells. CD19 and CD22 are transmembrane
proteins upregulated on malignant B cells.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of B-cell cancer.
It contains an antibody linked to a toxic substance. The antibody binds to proteins
called CD19 and CD22 on the surface of B cells, and the toxic substance kills the
cells. It is a type of bispecific ligand-directed toxin.;
Molecule name : DT2219ARL;
NCI Metathesaurus CUI : CL408648;
Codes from synonyms : CDR0000648985;
Origin ID : C82375;
UMLS CUI : C2826131;
Semantic type(s)
- concept_is_in_subset
- has_target
