Alpha-1-Proteinase Inhibitor Human

Preferred Label : Alpha-1-Proteinase Inhibitor Human;

NCIt synonyms : A1AT; Alpha 1 Antitrypsin; Alpha-1 Antitrypsin; AAT; Alpha-1-Antiproteinase; A1PI;

NCIt related terms : .ALPHA.1-PROTEINASE INHIBITOR HUMAN; Glassia;

NCIt definition : Human serum-derived alpha-1 proteinase inhibitor (alpha-1-antitrypsin or AAT) with immunomodulating and anti-inflammatory activity. Upon administration, AAT reduces the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-32, IL-6, and proteinase 3, and induces the production of anti-inflammatory cytokines, such as IL-10 and the IL-1 receptor antagonist IL-1RN. This agent also downregulates heparan sulfate and reduces the expansion of cytotoxic effector T cells, interferes with the maturation of dendritic cells and increases T regulatory cells. Altogether, AAT may attenuate acute graft-versus-host disease (GvHD) and may facilitate graft acceptance and survival. In addition, AAT enhances levels of cAMP and activation of cAMP-dependent protein kinase A. AAT, a 52kD protein and serine protease inhibitor, belongs to the serpin superfamily.;

UNII : F43I396OIS;

CAS number : 9041-92-3;

Drug name : Aralast; Prolastin-C; Glassia;

Details

Origin ID

C82258;

UMLS CUI

C0795657;

Automatic exact mappings (from CISMeF team)
- Alpha 1 antitrypsin [LOINC component]
- Alpha-1 anti-trypsin [MedDRA Preferred Term]
- L-aspartate:2-oxoglutarate aminotransferase activity [GO term]
- Serpin peptidase inhibitor, clade a, member 1 [OMIM gene]
- adenylyl sulfate-ammonia adenylyltransferase [MeSH Supplementary Concept]
- alfa1 antitrypsin [ATC Code]
- alpha 1-Antitrypsin [MeSH Descriptor]
- alpha 1-Antitrypsin [MeSH concept]
- alpha1 anti-trypsin [SNOMED Notion]
- aminoadenosine triacid ester [MeSH Supplementary Concept]
- aortic aneurysm, thoracic [MeSH Descriptor]
- serpin family A member 1 [ORDO Gene]
- serpin family A member 1 [HGNC gene]
Currated CISMeF NLP mapping
- Human alpha1 proteinase inhibitor (substance) [SNOMED CT concept]
- Human alpha1 proteinase inhibitor (substance) [Inactive SNOMED CT concept]
- Human alpha1-proteinase inhibitor [SMS substance]
- SERPINA1 protein, human [MeSH Supplementary Concept]
- alpha-1-antitrypsin [Blood Transfusion thesaurus concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Human alpha1 proteinase inhibitor (product) [Inactive SNOMED CT concept]
- Human alpha1 proteinase inhibitor (substance) [Inactive SNOMED CT concept]
- Human alpha1 proteinase inhibitor (substance) [SNOMED CT concept]
- Product containing human alpha1 proteinase inhibitor (medicinal product) [SNOMED CT concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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