NCIt definition : The trisodium salt form of gadofosveset, an injectable, intravascular, amphiphilic
gadolinium-based contrast agent (GBCA) used with magnetic resonance angiography (MRA)
imaging. Gadofosveset is a stable gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA)
chelate derivative with a diphenylcyclohexylphosphate group. Upon injection, gadofosveset
binds reversibly to endogenous serum albumin which increases its intravascular retention
time compared to non-protein binding contrast agents. The serum albumin binding also
increases T1-relaxivity of gadofosveset. This produces an increase in signal intensity
of blood, thereby enhancing the visualization of blood vessels upon MRA and may aid
in the diagnosis of certain blood vessels and heart disorders.;