Certolizumab Pegol

Preferred Label : Certolizumab Pegol;

NCIt synonyms : CZP;

NCIt definition : A Fab fragment of a recombinant, humanized monoclonal antibody directed against the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and conjugated to polyethylene glycol (PEG), with anti-inflammatory activity. Upon administration, certolizumab binds to TNF-alpha and prevents the interaction of this cytokine with endogenous cell surface receptors, thereby rendering TNF-alpha inactive and inhibiting TNF-mediated inflammatory responses. TNF-alpha is a protein involved in inflammation, cell survival, and apoptosis. Pegylation of certolizumab allows for an improved pharmacokinetic profile.;

UNII : UMD07X179E;

CAS number : 428863-50-7;

Drug name : Cimzia;

Molecule name : PHA-738144; CDP 870; CDP870;

Chemical formula : C19H30N5O8S(C2H4O)n(C2H4O)n;

ChEBI ID : CHEBI:63585;

Details

Origin ID

C80972;

UMLS CUI

C1872109;

CISMeF manual mappings
- Certolizumab Pegol [MeSH Descriptor]
False automatic mappings
- Cataract 1, multiple types [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Certolizumab [LOINC component]
- Certolizumab Pegol [MeSH Descriptor]
- Certolizumab pegol (substance) [SNOMED CT concept]
- Product containing certolizumab pegol (medicinal product) [SNOMED CT concept]
- certolizumab pegol [ATC Code]
- certolizumab pegol [MeSH concept]
Validated automatic mappings to BTNT
- certolizumab pegol [ATC Code]
Validated automatic mappings to NTBT
- Certolizumab [LOINC component]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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