Equine Thymocyte Immune Globulin

Preferred Label : Equine Thymocyte Immune Globulin;

NCIt synonyms : Lymphocyte Immune Globulin, Anti-Thymocyte Globulin; Equine Anti-human Thymocyte Immunoglobulin; Horse ATG; eATG; Antithymocyte Globulin Horse; Horse Anti-thymocyte Globulin; Equine ATG; Antithymocyte Globulin Equine; Antithymocyte Globulin;

NCIt definition : A purified, concentrated and sterile solution of horse-derived gamma globulin obtained by the immunization of horses with human T-lymphocytes, with T-cell depleting and immunosuppressive activities. Upon administration, horse anti-thymocyte globulin (hATG) specifically recognizes, modulates and destroys T-lymphocytes. Although the exact mechanism of action by which hATG causes immunosuppression is not completely understood, it is likely caused by a combination of T-lymphocyte depletion, reduction in T-cell activation and modulation of their cytotoxic activities. Administering of hATG prior to transplantation may reduce the risk of graft-versus-host disease (GvHD).;

UNII : 475247QF1Z;

Drug name : Atgam;

NCI Metathesaurus CUI : CL554424;

Details

Origin ID

C80824;

UMLS CUI

C0359163;

Automatic exact mappings (from CISMeF team)
- Product containing lymphocyte immunoglobulin (medicinal product) [SNOMED CT concept]
- antilymphocyte serum [MeSH Descriptor]
See also inter- (CISMeF)
- Equine antithymocyte immunoglobulin (substance) [SNOMED CT concept]
- lymphoglobuline [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- antilymphocyte immunoglobulin (horse) [ATC Code]
Validated automatic mappings to BTNT
- antilymphocyte immunoglobulin (horse) [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Antithymocyte Globulin Equine Regimen [NCIt concept]
- Antithymocyte Globulin Equine/Cyclosporine Regimen [NCIt concept]
- Equine Anti-thymocyte Globulin/Prednisone/Tacrolimus Regimen [NCIt concept]
- Horse Antithymocyte Globulin/Tacrolimus Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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