Preferred Label : Reserpine;
NCIt related terms : (3beta,16beta,17alpha,18beta,20alpha)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic
Acid Methyl Ester;
NCIt definition : An alkaloid, derived from the roots of Rauwolfia serpentine and vomitoria, and an
adrenergic uptake inhibitor with antihypertensive effects. Reserpine is lipid soluble
and can penetrate blood-brain barrier. This agent binds and inhibits catecholamine
pump on the storage vesicles in central and peripheral adrenergic neurons, thereby
inhibiting the uptake of norepinephrine, dopamine serotonin into presynaptic storage
vesicles. This results in catecholamines and serotonin lingering in the cytoplasm
where they are destroyed by intraneuronal monoamine oxidase, thereby causing the depletion
of catecholamine and serotonin stores in central and peripheral nerve terminals. Depletion
results in a lack of active transmitter discharge from nerve endings upon nerve depolarization,
and consequently leads to a decreased heart rate and decreased arterial blood pressure
as well as sedative effects.;
UNII : 8B1QWR724A;
InChIKey : QEVHRUUCFGRFIF-MDEJGZGSSA-N;
CAS number : 50-55-5;
Chemical formula : C33H40N2O9;
NSC code : 59272;
ChEBI ID : CHEBI:28487;
Codes from synonyms : NSC0059272; 01182;
PubMed : 18362193;
Origin ID : C803;
UMLS CUI : C0035179;
CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
