Preferred Label : Topotecan Hydrochloride Liposomes;
NCIt definition : The hydrochloride salt of a semisynthetic derivative of camptothecin mixed with sphingomyelin/cholesterol
and sonicated to form small unilamellar vesicles containing topotecan, with potential
antineoplastic activity. Topotecan hydrochloride liposomes mediates efficient drug
delivery of topotecan into the cytosol from the endosome compartment. During the S
phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent
complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks
and producing potentially lethal double-strand DNA breaks when complexes are encountered
by the DNA replication machinery.;
Drug name : Brakiva;
NCI Metathesaurus CUI : CL388400;
Origin ID : C80065;
UMLS CUI : C2699969;
Semantic type(s)
- concept_is_in_subset
- has_target
