" /> Lacnotuzumab - CISMeF





Preferred Label : Lacnotuzumab;

NCIt synonyms : Anti-M-CSF Monoclonal Antibody MCS110;

NCIt definition : A humanized monoclonal antibody directed against macrophage colony-stimulating factor (M-CSF) with potential anti-osteolytic activity. Lacnotuzumab binds to M-CSF and blocks M-CSF-mediated signaling through the M-CSF receptor CD116 expressed on osteoclasts, which may result in inhibition of M-CSF-induced osteoclast differentiation and so osteoclastic bone resorption. Osteoclasts are derived through the fusion of cells of the monocyte/macrophage lineage. Osteoblasts and stromal cells may react to bone metastases by producing M-CSF and its osteoclastogenic cofactor RANKL (receptor activator of NF-kappaB ligand).;

UNII : 77624NN1TU;

CAS number : 1831128-32-5;

Molecule name : MCS110;

NCI Metathesaurus CUI : CL388401;

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01/06/2025


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